Features of humoral immunity in persons with post-COVID syndrome burdened by history of allergy

From December 2019 to March 2020, the human population faced a new coronavirus pandemic, COVID-19, caused by SARS-CoV-2, which led to global morbidity and high mortality worldwide. Typical features of coronavirus infection tended to resemble a seasonal infection over time. Despite this fact, it has been proven that, after acute disease, numerous disorders are detected in the patients, manifesting both with general health disturbances and as complications of pre-existing chronic diseases, including allergic syndrome. On the basis of these findings, the study of post-COVID syndrome became an important aspect of the ongoing COVID-19 research. It has been shown over recent decades that the number of people suffering from various types of allergic reactions is growing every year. Therefore, the studies in allergic pathology in the structure of post-COVID syndrome are among the most pressing issues. In addition to studying exacerbations of allergic reactions, a thorough analysis has shown that adverse reactions caused by coronavirus infection are viewed from new aspects, being characterized by functional disorders of acquired and innate immune response, causing increasingly severe consequences for the immune system and the whole body. Currently, the features of humoral immune response in post-COVID syndrome have not been sufficiently studied. In this respect, we have evaluated the features of humoral immunity in patients with post-COVID syndrome, with clinically confirmed allergic anamnesis. The study revealed changes in humoral immune system, indicating that the most significant changes are observed in post-COVID patients with a burdened history of allergies, thus requiring a more detailed study of immune status in order to develop an individualized approach to immunocorrection of these disorders in this group of patients.