About adverse events of targeted therapy for polypous rhinosinusitis

The study of biologically active inflammatory mediators is important in the diagnosis of allergic rhinitis. The aim of the present study was to evaluate the levels of secretory immunoglobulin A (sIgA) in nasal secretions in the upper respiratory tract allergies in patients living in various cities of the Russian Federation. Patients and methods. We examined 86 patients aged 28 to 40 years (men-to-women ratio was 1:1 in patients and control group) with a persistent form of allergic rhinitis living in various cities of Russian Federation (Chelyabinsk, Moscow). Group 1 included 36 patients with newly diagnosed allergic rhinitis who did not take any medications (subgroup 1a included 18 persons living in Chelyabinsk; 1b consisted of 18 patients living in Moscow). Group 2 included 30 patients who received long-term intranasal steroid medications (4.9±0.9 months): 2a, patients who lived in Chelyabinsk (n = 15), and 2b lived in Moscow (n = 15). Control group 3 included twenty healthy volunteers aged 28 to 40 years. The disease symptoms were documented in the patients, nasal secretions were collected by endoscopy, and the samples were analyzed by enzyme immunoassay (ELISA). It has been shown that the levels of secretory immunoglobulin A (sIgA) in nasal secretions showed a significant (p 0.05) unidirectional decrease in adult patients with allergic rhinitis living in various cities of the Russian Federation.