Identification and experimental validation of diagnostic and prognostic genes CX3CR1, PID1 and PTGDS in sepsis and ARDS using bulk and single-cell transcriptomic analysis and machine learning
This study identified three molecular signatures (CX3CR1, PID1 and PTGDS) linked to the diagnosis and poor prognosis of sepsis and ARDS, validated by RT-qPCR and H&E staining in both patient and mouse samples. This research may be valuable for identifying shared biological mechanisms and potential treatment targets for both diseases.
Authors
- Jie Jiang (ORCID: https://orcid.org/0000-0003-3795-672X)
- Yue Su (ORCID: https://orcid.org/0000-0001-8705-2783)
- Yan Chen (ORCID: https://orcid.org/0000-0002-3266-0578)
- Jin‐Fu Xu (ORCID: https://orcid.org/0000-0002-8039-8973)
- Hao Qian (ORCID: https://orcid.org/0000-0001-7808-6009)
- Xinmiao Song
- Li Zhang (ORCID: https://orcid.org/0000-0002-1231-8927)
Institutions
- Tongji University (CN)
- Shanghai Pulmonary Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-12-23
- DOI
- https://doi.org/10.3389/fimmu.2024.1480542
- Citations
- 7
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.68