A novel role for nonactin: interfering with G-quadruplex in RET-driven medullary thyroid cancer
The findings highlight the compound's therapeutic potential, emphasizing its mechanism of inducing apoptosis in active mutant RET cell lines by interacting with G-quadruplex structures. This novel insight opens avenues for a potentially effective treatment for MTC, potentially bypassing the challenges associated with current TKIs.
Authors
- Sahar S. Alghamdi (ORCID: https://orcid.org/0000-0002-2770-218X)
- Ahmad Alamer (ORCID: https://orcid.org/0000-0002-2091-1376)
- Osama I. Alwassil (ORCID: https://orcid.org/0000-0002-6572-8321)
- Ahmad J. Obaidullah (ORCID: https://orcid.org/0000-0002-7532-6318)
- Tariq Alqahtani (ORCID: https://orcid.org/0009-0007-1094-6835)
- Arwa Alsubait
- Meshari Aloumi
- Ghala Alomari
Institutions
- King Saud bin Abdulaziz University for Health Sciences (SA)
- King Saud University (SA)
- King Abdullah International Medical Research Center (SA)
- National Guard Health Affairs (SA)
Publication Details
- Journal
- BMC Cancer
- Published
- 2024-12-23
- DOI
- https://doi.org/10.1186/s12885-024-13345-9
- Citations
- 2
- Primary Topic
- RNA and protein synthesis mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.47
Funders
- King Abdullah International Medical Research Center
- King Saud bin Abdulaziz University for Health Science