Mll4 in skeletal muscle fibers maintains muscle stem cells
Our study suggests that Mll4 is crucial for maintaining MuSCs in both pubertal and adult muscles, which may be accomplished through the modulation of distinct Notch ligand expressions in myofibers. These findings offer new insights into the role of myofiber-expressed Mll4 as a master regulator of MuSCs, highlighting its significance not only in developmental myogenesis but also in adult muscle, irrespective of sex.
Authors
- Kyusang Yoo (ORCID: https://orcid.org/0000-0002-9852-5344)
- Yea-Eun Kim
- Sang-Hyeon Hann
- Ji-Hoon Kim (ORCID: https://orcid.org/0000-0002-9217-4483)
- Jae W. Lee (ORCID: https://orcid.org/0000-0001-7439-643X)
- Young-Woo Jo
- Young‐Yun Kong (ORCID: https://orcid.org/0000-0001-7335-3729)
Institutions
- Seoul National University (KR)
- Korea Institute of Science and Technology (KR)
- University at Buffalo, State University of New York (US)
Publication Details
- Journal
- Skeletal Muscle
- Published
- 2024-12-22
- DOI
- https://doi.org/10.1186/s13395-024-00369-9
- Citations
- 1
- Primary Topic
- Muscle Physiology and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.23
Funders
- National Research Foundation of Korea
- National Institute of Neurological Disorders and Stroke