Effects of two different dexamethasone dosing regimens on ventilator-free days and long-term mortality in COVID-19 patients with moderate-to-severe ARDS: the REMED randomized clinical trial
Despite not reaching its prespecified enrollment, there was no signal to either benefit or harm high-dose dexamethasone over standard-dose dexamethasone in patients with COVID-19 and moderate-to-severe ARDS. Trial registration Trial registration: ClinicalTrials.gov Identifier: NCT04663555. Registered 10 December 2020, https://clinicaltrials.gov/study/NCT04663555?term=NCT04663555&rank=1 and EudraCT: 2020-005887-70.
Authors
- Milan Kratochvíl (ORCID: https://orcid.org/0000-0001-6070-1616)
- Jan Varady
- Jiří Pouska
- Martin Kolář (ORCID: https://orcid.org/0000-0001-9501-0604)
- Petr Suk
- Tereza Šobáňová
- Jan Rulíšek (ORCID: https://orcid.org/0000-0002-9063-313X)
- Marek Fencl
- Jana Vinklerová
- Mervyn Singer (ORCID: https://orcid.org/0000-0002-1042-6350)
- Michal Otáhal
- Adam Svobodník
- Václav Zvoníček
- Ivan Čundrle (ORCID: https://orcid.org/0000-0002-7709-8021)
- Karolína Grodová
- Michal Fric
- Martin Kutěj
- Tomáš Tyll (ORCID: https://orcid.org/0000-0003-4000-3495)
- Lenka Doubravská (ORCID: https://orcid.org/0000-0001-5354-8684)
- Pavel Suk (ORCID: https://orcid.org/0000-0001-5292-2654)
- Filip Haiduk
- Jana Kubátová (ORCID: https://orcid.org/0000-0001-9727-4136)
- Jan Hudec (ORCID: https://orcid.org/0000-0002-1781-2537)
- Jan Maláska (ORCID: https://orcid.org/0000-0002-6911-2575)
- Jozef Klučka (ORCID: https://orcid.org/0000-0003-4449-0411)
- Martin Balík (ORCID: https://orcid.org/0000-0003-1864-2143)
- Jan Máca (ORCID: https://orcid.org/0000-0002-9771-0468)
- Tomáš Graus
- Tomáš Gabrhelík
- Marcela Káňová (ORCID: https://orcid.org/0000-0001-8880-8925)
- Petr Štourač (ORCID: https://orcid.org/0000-0003-1944-5926)
- Peter Sklienka (ORCID: https://orcid.org/0000-0002-0330-5323)
- Pavel Štětka
- Pavel Novotný (ORCID: https://orcid.org/0000-0001-7325-6961)
- Miloš Chobola
- Jakub Kletečka (ORCID: https://orcid.org/0000-0003-0409-4916)
- František Duška (ORCID: https://orcid.org/0000-0003-1559-4078)
- P Kafka (ORCID: https://orcid.org/0000-0001-7801-1680)
- Helena Antoni
- Radovan Turek
- Jan Zatloukal
- Tomáš Tencer (ORCID: https://orcid.org/0000-0002-9111-6556)
- Olga Klementová (ORCID: https://orcid.org/0000-0003-0902-5928)
- Jan Stašek (ORCID: https://orcid.org/0000-0002-8379-2503)
- Vladimír Šrámek (ORCID: https://orcid.org/0000-0002-6283-4073)
- Filip Burša (ORCID: https://orcid.org/0000-0001-9770-1433)
- Marek Flaksa
- Regina Demlová (ORCID: https://orcid.org/0000-0002-3797-4453)
- Tomáš Korbička
- Aleš Rára
- Eva Svobodová (ORCID: https://orcid.org/0000-0003-3469-9684)
- Radka Štěpánová (ORCID: https://orcid.org/0000-0001-6020-8100)
- Jan Hruda (ORCID: https://orcid.org/0000-0002-0973-3054)
- Marek Lukeš
- Libor Číž
Institutions
- Charles University (CZ)
- Masaryk University (CZ)
- Bury College (GB)
- University Hospital Ostrava (CZ)
- University Hospital Brno (CZ)
- University Hospital Olomouc (CZ)
- Military University Hospital Prague (CZ)
- St. Anne's University Hospital Brno (CZ)
- University Hospital Kralovske Vinohrady (CZ)
- General University Hospital in Prague (CZ)
- University College London (GB)
- Palacký University Olomouc (CZ)
Publication Details
- Journal
- European journal of medical research
- Published
- 2024-12-23
- DOI
- https://doi.org/10.1186/s40001-024-02215-6
- Citations
- 4
- Primary Topic
- Respiratory Support and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.68
Funders
- Ministerstvo Školství, Mládeže a Tělovýchovy
- Všeobecná Fakultní Nemocnice v Praze