A shielded cascade of targeted nanocarriers spanning multiple microenvironmental barriers for inflammatory disease therapy
FA-PTP@Que combines active chemotaxis of nanocarriers to inflammatory tissues and active targeting of effector cells, acting precisely at each barrier level in different microenvironments by responding to inflammatory mediators and overcoming the multiple barriers in the inflammatory microenvironment. This innovative strategy can effectively break through various inflammatory microenvironments and has the potential application to other inflammatory diseases.
Authors
- Yuzhou Li (ORCID: https://orcid.org/0000-0003-1768-1140)
- Xu Wang (ORCID: https://orcid.org/0000-0002-9757-2923)
- Sheng Yang (ORCID: https://orcid.org/0000-0002-3274-7550)
- Mingxing Ren (ORCID: https://orcid.org/0000-0003-0190-7088)
- Fengyi Liu (ORCID: https://orcid.org/0009-0007-0597-5498)
- Ping He (ORCID: https://orcid.org/0000-0002-8047-1157)
- Jing Cui (ORCID: https://orcid.org/0000-0001-8098-1678)
Institutions
- Chongqing University (CN)
- Stomatological Hospital of Chongqing Medical University (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Chongqing Municipal Government (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2024-12-23
- DOI
- https://doi.org/10.1186/s12951-024-03075-2
- Citations
- 4
- Primary Topic
- Nanoparticle-Based Drug Delivery
- Type
- article
- Field-Weighted Citation Impact
- 0.69
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Chongqing Medical University
- Natural Science Foundation of Chongqing
- Centre Scientifique et Technique du Bâtiment