Chronic sleep deprivation disturbs energy balance modulated by suprachiasmatic nucleus efferents in mice
Chronic SD impairs energy balance through directly dampening BMAL1 expression, probably in the transcription level, in the SCN, which in turn affects the neuron projections to ARC and PVN. Remarkably, we provide evidence that may explain the causal mechanisms associated with sleep curtailment and obesity in adolescents.
Authors
- Honghong Yu
- Lanyue Gao
- Tian Hu (ORCID: https://orcid.org/0000-0001-7280-1921)
- Tingting Du (ORCID: https://orcid.org/0000-0002-1350-6778)
- Qi Sun
- Lihong Jia (ORCID: https://orcid.org/0000-0003-3875-0598)
- Lina Huang (ORCID: https://orcid.org/0000-0003-2701-8369)
- Jiajin Hu
- Shuailing Liu
- Yu Yang (ORCID: https://orcid.org/0000-0002-1603-3603)
Institutions
- Shenyang Center for Disease Control and Prevention (CN)
- China Medical University (CN)
Publication Details
- Journal
- BMC Biology
- Published
- 2024-12-23
- DOI
- https://doi.org/10.1186/s12915-024-02097-4
- Citations
- 5
- Primary Topic
- Circadian rhythm and melatonin
- Type
- article
- Field-Weighted Citation Impact
- 1.37
Funders
- National Natural Science Foundation of China
- China Medical University
- Department of Science and Technology of Liaoning Province