Neoadjuvant chemoradiotherapy up-regulates PD-L1 in radioresistant colorectal cancer
This study demonstrated that radiation induces an increase in PD-L1 expression, which is more pronounced in radioresistant CRC, proving the theoretical framework for a combined treatment strategy with a PD-L1 blockade for locally advanced rectal cancer.
Authors
- Jee Young Park
- Ju Yup Lee (ORCID: https://orcid.org/0000-0003-0021-5354)
- Sang Jun Byun
- Incheol Seo (ORCID: https://orcid.org/0000-0002-3271-381X)
- Seong Kyu Baek (ORCID: https://orcid.org/0000-0001-6427-8675)
- Sung Uk Bae (ORCID: https://orcid.org/0000-0002-7876-4196)
- Shin Kim (ORCID: https://orcid.org/0000-0002-1099-5027)
- Nam Kyu Kim (ORCID: https://orcid.org/0000-0003-0639-5632)
- Jin Young Kim (ORCID: https://orcid.org/0000-0002-9597-9834)
- Yoo Jin Lee (ORCID: https://orcid.org/0000-0003-3830-7051)
- Hye Won Lee (ORCID: https://orcid.org/0000-0001-8540-524X)
- Jae-Min Cho (ORCID: https://orcid.org/0009-0005-4946-2024)
Institutions
- Yonsei University (KR)
- Severance Hospital (KR)
- Kyungpook National University (KR)
- Keimyung University (KR)
Publication Details
- Journal
- Clinical and Translational Radiation Oncology
- Published
- 2024-12-22
- DOI
- https://doi.org/10.1016/j.ctro.2024.100906
- Citations
- 1
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.28
Funders
- National Research Foundation
- Ministry of Science, ICT and Future Planning
- National Research Foundation of Korea