Network pharmacology, transcriptomics, and biological validation reveal a lipid secretion inhibitory and anti-inflammatory mechanism of tanreqing gel in the treatment of acne
This study demonstrated that TRQ effectively alleviates C. acnes-induced acne symptoms by inhibiting sebum secretion and inflammatory responses through multiple pathways and targets. It provides new insights and directions for acne treatment.
Authors
- Xinyu Gao (ORCID: https://orcid.org/0000-0001-7404-4119)
- Li Lu (ORCID: https://orcid.org/0000-0003-0977-6414)
- Na Zhou (ORCID: https://orcid.org/0009-0006-6214-8061)
- Lishuang Li
- Yunong Wang (ORCID: https://orcid.org/0000-0001-5552-5830)
- Yi Wang (ORCID: https://orcid.org/0000-0001-8043-4869)
- Yanan Sun (ORCID: https://orcid.org/0000-0002-2586-3633)
- Yuman Ma
- Yujia Zhao (ORCID: https://orcid.org/0000-0002-7186-1727)
- Dongying Li (ORCID: https://orcid.org/0000-0003-0721-2500)
- Xing Ren
Institutions
- Beijing University of Chinese Medicine (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- China Academy of Chinese Medical Sciences (CN)
Publication Details
- Journal
- Journal of Ethnopharmacology
- Published
- 2024-12-22
- DOI
- https://doi.org/10.1016/j.jep.2024.119278
- Citations
- 3
- Primary Topic
- Acne and Rosacea Treatments and Effects
- Type
- article
- Field-Weighted Citation Impact
- 1.60