Evaluation of the cumulative efficacy of the combined administration of «Speroton» and «Sinergin» in patients with male infertility

Introduction . Infertility is a serious problem of modern medicine, affecting 15% of couples worldwide. In 25- 87% of cases, the male factor of infertility is mediated by oxidative stress. An effective way to eliminate oxidative stress is the use of antioxidant supplements. To date, the question remains open about the effect of combined drugs – which components and in what proportions can provide the optimal therapeutic effect. The purpose of this study was to evaluate the effect of the «Speroton» and «Sinergin» complexes separately and in combination with each other on bulk semen analysis parameters and accessory spermiological tests. The patient was asymptomatic and the lesion was accidental finding on the CT scan. Materials and methods . The study included 90 patients, whose ages ranged from 25 to 45. In the first group, 30 patients received «Speroton» 1 sachet per day for 3 months, in the second group, 30 patients received «Sinergin» 2 capsules per day for 3 months, in the third group, 30 patients received both drugs at the prescribed dosage. At the time of inclusion in the study and after 3 months of therapy, patients underwent a semen analysis, an assessment of the index of sperm DNA fragmentation and the level of generation of reactive oxygen species. Results . In patients taking «Speroton», a moderate positive effect was observed with respect to sperm concentration, an increase in sperm motility was noted, as well as a significant decrease in the generation of reactive oxygen species and, accordingly, the DNA fragmentation index. The «Sinergin» complex in the form of monotherapy led to a moderate increase in sperm concentration and motility, but had practically no effect on the results of additional functional tests. Combination therapy («Speroton» and «Sinergin») surpassed both types of monotherapy in terms of its effect on the number of spermatozoa (the average increased from 62.4 million to 100 million), the total number of motile spermatozoa (from 11.38 million to 34 million), the DNA fragmentation index (from 21% to 7%) and the level of generation of reactive oxygen species (from 66.09 mV to 17.64 mV). Conclusion . Antioxidant complexes have a positive effect on various spermological parameters. The combination of «Speroton» and «Sinergin» has the most pronounced effect on the intensity of oxidative stress and the index of fragmentation of sperm DNA, as well as on the basic parameters of the spermogram.