The Development of Signs of Alzheimer’s Disease in OXYS Rats is Accompanied by a Decrease in the Expression of Cerebral Dopamine Neurotrophic Factor (CDNF), and is not Compensated by Its Overexpression

Alzheimer’s disease (AD) is the most common neurodegenerative disease leading to senile dementia. It is known that the processes of neurodegeneration are closely related to neurotrophic support. In this work, carried out on a model of AD - the OXYS line of rapidly aging rats, CDNF deficiency in the hippocampus was first identified, and an attempt was made to compensate for it by inducing overexpression using an adeno-associated viral construct. The constructs were introduced into the dorsal hippocampus of rats at the age of three months. 15 months after the introduction of the construct, we showed overexpression of CDNF in the target structure, but did not detect its effect on the learning and memory of animals in the Morris water maze, as well as on the accumulation of Aβ and Tau protein and the expression of genes involved in the unfolded protein response (UPR).