Aldo-keto reductase family 1 member B10 prevents esophageal squamous cell carcinoma from reactive carbonyl species-induced cell death and promotes its progression
Our findings suggested that AKR1B10 is an independent adverse prognosticator for patients with ESCC, and could prevent ESCC neoplastic cells from undergoing RCS-induced apoptosis, and promote ESCC progression. Therefore, AKR1B10 signaling could be a potential therapeutic strategy for ESCC.
Authors
- Shau-Hsuan Li (ORCID: https://orcid.org/0000-0002-7140-9132)
- Yen‐Hao Chen (ORCID: https://orcid.org/0000-0002-5622-5490)
- Hung‐I Lu (ORCID: https://orcid.org/0000-0002-3564-1604)
- Chang‐Han Chen (ORCID: https://orcid.org/0009-0009-8342-5680)
- Wan‐Ting Huang (ORCID: https://orcid.org/0000-0002-4344-9567)
- Hsin‐Ting Tsai
- Chien-Ming Lo
Institutions
- Chang Gung University (TW)
- National Chi Nan University (TW)
- Taichung Veterans General Hospital (TW)
- Kaohsiung Chang Gung Memorial Hospital (TW)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2024-12-22
- DOI
- https://doi.org/10.1186/s12935-024-03623-8
- Citations
- 1
- Primary Topic
- Aldose Reductase and Taurine
- Type
- article
- Field-Weighted Citation Impact
- 0.33
Funders
- National Science Council
- Chang Gung Medical Foundation
- Taichung Veterans General Hospital
- National Science and Technology Council
- Kaohsiung Chang Gung Memorial Hospital