Spatiotemporal metabolic mapping of ex-situ preserved hearts subjected to dialysis by integration of bio-SPME sampling with non-targeted metabolipidomic profiling
Through implementing the unique analytical pipeline we demonstrated that the addition of dialysis may preserve cardiac metabolism allowing for prolonged ESHP. This strategy has the potential to facilitate high-risk donor organs' reconditioning prior to transplantation.
Authors
- V. Bissoondath
- Filio Billia (ORCID: https://orcid.org/0000-0002-2824-1215)
- Karol Jaroch (ORCID: https://orcid.org/0000-0003-0189-2509)
- Mitesh Badiwala (ORCID: https://orcid.org/0000-0003-4377-4164)
- Janusz B. Pawliszyn (ORCID: https://orcid.org/0000-0002-9975-5811)
- Liming Xin (ORCID: https://orcid.org/0000-0002-3447-9932)
- Mariola Olkowicz (ORCID: https://orcid.org/0000-0001-8759-3192)
- Miao Yu (ORCID: https://orcid.org/0000-0002-2804-6014)
- Roberto Vanin Pinto Ribeiro (ORCID: https://orcid.org/0000-0003-0906-0539)
- M. Adamson (ORCID: https://orcid.org/0000-0003-4386-6130)
- Juglans Alvarez
- Frank Yu
- Roizar Rosales
Institutions
- University Health Network (CA)
- University of Waterloo (CA)
- University of Gdańsk (PL)
- Ted Rogers Centre for Heart Research (CA)
- Jackson Laboratory (US)
Publication Details
- Journal
- Analytica Chimica Acta
- Published
- 2024-12-22
- DOI
- https://doi.org/10.1016/j.aca.2024.343581
- Citations
- 1
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.23
Funders
- Natural Sciences and Engineering Research Council of Canada