Association between Some Reproductive Hormones and Breast Cancer Progression in Premenopausal Women

Breast cancer (BC) grows in a hormone-rich environment, which affected its clinical behaviour and biological features. In premenopausal women, BC tends to be detected in advanced stages and this may be a consequence of that young women are not the screening programs focus. This study aimed to evaluate the association between reproductive-related hormones: Circulating follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin (PRL) and progesterone (PRG) and BC progression worse outcomes. Circulating hormones levels were measured in 100 premenopausal BC patients and 40 age-matched healthy women. Results revealed that there was no significant difference in the serum level of FSH (P=0.486), LH (P=0.806), PRL (P=0.081) and PRG (P=0.474) hormones between BC cases and healthy controls. Moreover, in premenopausal BC patients, these reproductive hormones were also not significantly (P>0.05) influenced the disease progression including tumor late stages, lymph node invasion, distant metastasis, high grades, large size, negative progesterone and estrogen receptors and negative HER2 status. In conclusion, circulating FSH, LH, PRG and PRL levels seem to be not associated with BC development and/or progression. This is very important knowledge that the BC and its possible progression have no effect on the reproductive hormones and consequently on the young women fertility.