Beyond the Gut Feeling: Exploring the role of “Psychomicrobiotic” and Biomeme Hypothesis

Abstract Introduction: Recent studies suggests that human gut microbiota might affect the human nervous system and correlate with psychological and behavioural phenotypes, including mood, cognition, sleep, and personality. The cross-talk is also known as the “microbiota-gut-brain axis,” which plays important role in the development as well as the function of the brain in health and disease states. Likewise, dysbiosis of the gut microbiota (GM) like perturbations and alterations is linked with anxiety, depression, and even a variety of neuropsychiatric diseases. Materials and method: Currently available of published articles, systemic reviews, or meta-analyses were identified through literature search from Scopus, Web of Science and PubMed, since the inception of databases to December 2019. Herewith, the titles, abstracts, and full-text articles were screened for the selection of relevant papers. Results: This review describes the clinical application of GBA in managing major psychiatric illness in adult (Psychomicrobiotic). Conclusion: Further research is recommended as there is a demand for high-quality research to established the association between psychiatric illness and human gut microbiome. Keywords: Microbiome-gut-brain axis, microbiome.