Cardiac power and the association with heart failure and cardiovascular death in the general population

During a median follow-up of 3.5 years (IQR 2.6;4.4 years), 134 (3.3 %) individuals experienced the composite outcome. Left ventricular (LV) ejection fraction (LVEF) significantly modified the association between CP and outcome (p_interaction < 0.001). Stratifying the population according to LVEF, CP had no prognostic value in LVEF ≥50 % (p = 0.81). In individuals with LVEF <50 %, CP remained significantly associated with the composite outcome after multivariable adjustment (HR 1.22 per 0.1 W decrease, 95 % CI: 1.06-1.41, p = 0.005). Individuals with reduced LVEF and CP <0.84 W had the highest risk of the composite outcome (SHR 7.45 per 0.1 W decrease, CI: 4.63-12.00, p < 0.001.) CONCLUSION: CP was associated with incident HF and CV death in the general population, however, LVEF significantly modified this relationship. CP was independently associated with incident HF and CV death in individuals with LVEF <50 % but not individuals with LVEF ≥50 %.