Alpha‐synuclein <scp>RT</scp>‐<scp>QuIC</scp> assay in gastroduodenal and skin biopsies of Parkinson disease patients
In this study, we compared the value of pathological alpha-synuclein (αSyn) seed amplification assay (SAA) in gastric and duodenal biopsies with skin biopsies in Parkinson disease (PD) patients with different disease duration. The accuracy of αSyn SAA was 87.7% in skin, 67.4% in duodenum, and 80.0% in gastric biopsies, with significantly higher sensitivity in advanced PD (skin: 81.8%; gastric: 88.9%; duodenal 58.8%). Misfolded αSyn was detected with higher sensitivity in advanced PD across all matrices, likely reflecting the progression of αSyn pathology. The seeding activity was lower in the duodenal than in the gastric wall, indicating differences in αSyn burden.
Authors
- Andrea Porzionato (ORCID: https://orcid.org/0000-0003-3025-4717)
- Simone Baiardi (ORCID: https://orcid.org/0000-0002-7702-7856)
- Angela Mammana (ORCID: https://orcid.org/0000-0002-6237-8784)
- Piero Parchi (ORCID: https://orcid.org/0000-0002-9444-9524)
- Francesco Paolo Russo (ORCID: https://orcid.org/0000-0003-4127-8941)
- Marcello Rossi (ORCID: https://orcid.org/0000-0002-8125-6571)
- Marta Campagnolo (ORCID: https://orcid.org/0000-0002-6394-7168)
- Angelo Antonini (ORCID: https://orcid.org/0000-0003-1040-2807)
- Franco Magliocchetti (ORCID: https://orcid.org/0009-0004-3894-8419)
- Luca Weis (ORCID: https://orcid.org/0000-0002-2286-0795)
- Miryam Carecchio (ORCID: https://orcid.org/0000-0002-0755-5477)
- Edoardo Vincenzo Savarino (ORCID: https://orcid.org/0000-0002-3187-2894)
- Michele Sandre (ORCID: https://orcid.org/0000-0002-3013-6908)
- Aron Emmi (ORCID: https://orcid.org/0000-0002-2796-5676)
Institutions
- University of Padua (IT)
- Neuroscience Institute (IT)
- Istituto delle Scienze Neurologiche di Bologna (IT)
- IRCCS San Camillo Hospital (IT)
- University of Bologna (IT)
Publication Details
- Journal
- Annals of Clinical and Translational Neurology
- Published
- 2024-12-21
- DOI
- https://doi.org/10.1002/acn3.52282
- Citations
- 5
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.85