<i>Escherichia coli</i> Nissle Improves Short-Chain Fatty Acid Absorption and Barrier Function in a Mouse Model for Chronic Inflammatory Diarrhea
These findings suggest that EcN is able to proliferate in the inflamed cecum, resulting in increased microbial SCFA production, decreased inflammation, and improved gut barrier properties. In sufficient dosage, probiotics may thus be an effective anti-inflammatory strategy in the diseased gut.
Authors
- Ursula Elisabeth Seidler (ORCID: https://orcid.org/0000-0002-9600-2769)
- Guntram A. Graßl (ORCID: https://orcid.org/0000-0003-3718-2090)
- Archana Kini
- Marius Vital
- Dorothee Römermann
- Zhenghao Ye
- Sabrina Woltemate (ORCID: https://orcid.org/0009-0000-9495-470X)
- Qinghai Tan (ORCID: https://orcid.org/0000-0002-6095-109X)
- Xinjie Tan
Institutions
- Medizinische Hochschule Hannover (DE)
- German Center for Infection Research (DE)
- Huazhong University of Science and Technology Hospital (CN)
- Tongji Hospital (CN)
- First Affiliated Hospital Zhejiang University (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Inflammatory Bowel Diseases
- Published
- 2024-12-21
- DOI
- https://doi.org/10.1093/ibd/izae294
- Citations
- 6
- Primary Topic
- Helicobacter pylori-related gastroenterology studies
- Type
- article
- Field-Weighted Citation Impact
- 3.44
Funders
- Deutsche Forschungsgemeinschaft
- China Scholarship Council