Synaptic modulation of glutamate in striatum of the YAC128 mouse model of Huntington disease
These findings suggest that YAC128 corticostriatal slices show increased D2 sensitivity that is eCB-dependent, and that dopamine and eCB release are altered at an early disease stage. We provide evidence for impaired neuromodulatory signaling in early HD, guiding therapeutic efforts prior to the onset of overt motor symptoms later on.
Authors
- Timothy P. O’Leary (ORCID: https://orcid.org/0000-0003-4304-2772)
- Daniel Ramandi (ORCID: https://orcid.org/0000-0003-2995-154X)
- Ellen T. Koch (ORCID: https://orcid.org/0000-0002-8661-2205)
- Lynn A. Raymond (ORCID: https://orcid.org/0000-0002-8610-1042)
- James P. Mackay (ORCID: https://orcid.org/0000-0002-0143-4391)
- Judy Cheng (ORCID: https://orcid.org/0000-0002-6571-021X)
- William Rees-Jones
Institutions
- University of British Columbia (CA)
Publication Details
- Journal
- Neurobiology of Disease
- Published
- 2024-12-21
- DOI
- https://doi.org/10.1016/j.nbd.2024.106774
- Citations
- 1
- Primary Topic
- Genetic Neurodegenerative Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.27