SIRT6 deficiency impairs the deacetylation and ubiquitination of UHRF1 to strengthen glycolysis and lactate secretion in bladder cancer
Together, our study uncovered an epigenetic mechanism of the SIRT6/UHRF1 axis in driving BLCA glycolysis and lactate secretion, creating a novel vulnerability for BLCA treatment.
Authors
- Hongjing Dou (ORCID: https://orcid.org/0000-0001-5850-9174)
- Jingyi Huang (ORCID: https://orcid.org/0000-0001-5590-8954)
- Hongchao He (ORCID: https://orcid.org/0000-0003-4225-1142)
- Peipei Zhang (ORCID: https://orcid.org/0000-0003-3680-1136)
- Jiaqi Yan (ORCID: https://orcid.org/0000-0002-2801-6691)
- Yan Shen (ORCID: https://orcid.org/0000-0002-1826-9134)
- Xiaojing Wang
Institutions
- Shanghai Jiao Tong University (CN)
- Ruijin Hospital (CN)
Publication Details
- Journal
- Cell & Bioscience
- Published
- 2024-12-21
- DOI
- https://doi.org/10.1186/s13578-024-01333-2
- Citations
- 6
- Primary Topic
- Sirtuins and Resveratrol in Medicine
- Type
- article
- Field-Weighted Citation Impact
- 2.07
Funders
- National Natural Science Foundation of China
- Shanghai Jiao Tong University