MLH1 gene promoter methylation status partially overlaps with CpG methylator phenotype (CIMP) in colorectal adenocarcinoma
Our study demonstrates that pMLH1 hypermethylation, MMRd, BRAF<sup>mut</sup> and CIMP phenotype do not completely overlap in CRC. These findings further refine the knowledge on the molecular landscape of CRC and may have critical implications also for the clinical management of the disease.
Authors
- Federica Grillo (ORCID: https://orcid.org/0000-0001-6477-3182)
- Valentina Angerilli (ORCID: https://orcid.org/0000-0002-9799-9257)
- Paola Parente (ORCID: https://orcid.org/0000-0003-0591-6723)
- Angelo Paolo Dei Tos (ORCID: https://orcid.org/0000-0002-1228-8940)
- Francesca Bergamo (ORCID: https://orcid.org/0000-0002-8795-4653)
- Marco Scarpa (ORCID: https://orcid.org/0000-0002-0217-6523)
- Matteo Fassan (ORCID: https://orcid.org/0000-0001-6515-5482)
- Francesca Schiavi (ORCID: https://orcid.org/0000-0001-8529-4455)
- Chiara Borga (ORCID: https://orcid.org/0000-0003-0974-0323)
- Sara Lonardi (ORCID: https://orcid.org/0000-0002-7593-8138)
- Jessica Gasparello (ORCID: https://orcid.org/0000-0001-8557-0739)
- Claudio Luchini (ORCID: https://orcid.org/0000-0003-4901-4908)
- Carlotta Ceccon (ORCID: https://orcid.org/0009-0004-5478-9550)
- Stefania Zovato (ORCID: https://orcid.org/0000-0002-4295-3577)
- Giada Munari (ORCID: https://orcid.org/0000-0002-0872-4316)
- Emanuele Damiano Luca Urso (ORCID: https://orcid.org/0000-0002-2789-2470)
- Marianna Sabbadin (ORCID: https://orcid.org/0009-0004-7795-415X)
Institutions
- University of Verona (IT)
- University of Padua (IT)
- Casa Sollievo della Sofferenza (IT)
- AULSS 2 Marca Trevigiana (IT)
- Istituto Oncologico Veneto (IT)
- Ospedale Policlinico San Martino (IT)
- Azienda Ospedale - Università Padova (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
Publication Details
- Journal
- Pathology - Research and Practice
- Published
- 2024-12-21
- DOI
- https://doi.org/10.1016/j.prp.2024.155786
- Citations
- 6
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 2.55