Unraveling the causal pathways of maternal smoking and breastfeeding in the development of neuropsychiatric disorders: A Mendelian randomization perspective
This study shows that maternal smoking around the time of birth increases the risk of attention-deficit/hyperactivity disorder (ADHD), major depressive disorder (MDD), bipolar disorder (BD), and anxiety disorders (ANX). In contrast, breastfeeding during infancy offers protective benefits against ADHD, MDD, and ANX. These findings underscore the vital importance of maternal health behaviours during the perinatal and infant feeding periods. They also highlight the need for targeted public health interventions aimed at reducing the risk of neuropsychiatric disorders.
Authors
- Chenggang Jiang (ORCID: https://orcid.org/0000-0002-2240-831X)
- Zheng Zhang (ORCID: https://orcid.org/0000-0001-5149-8468)
- Liwei Tang
- Keyi Liu (ORCID: https://orcid.org/0000-0002-2188-0110)
- Cheng Gan (ORCID: https://orcid.org/0000-0002-2167-4966)
- Yuan H. Zhao (ORCID: https://orcid.org/0000-0002-5351-502X)
- Ying Liu (ORCID: https://orcid.org/0000-0003-0802-3832)
- Li-Xia Chen (ORCID: https://orcid.org/0000-0003-3051-3192)
- Jing Wang (ORCID: https://orcid.org/0000-0003-4896-0142)
- Haitang Qiu
- Hao Ren
- Qiyin Li
- Yadong Peng
- Qinghua Luo
- Jiangyou Yu
Institutions
- Chongqing City Mental Health Center (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Children's Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Journal of Affective Disorders
- Published
- 2024-12-21
- DOI
- https://doi.org/10.1016/j.jad.2024.12.075
- Citations
- 2
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 1.10