Single-cell transcriptomics reveal the prognostic roles of epithelial and T cells and DNA methylation-based prognostic models in pancreatic cancer
scRNA-seq and DNAm data integration enabled the creation of predictive models based on epithelial and T cell-specific methylation patterns, offering robust prognosis prediction for PDAC patients.
Authors
- Hailang Fan
- Jing Du (ORCID: https://orcid.org/0000-0001-7519-8531)
- Dake Zhang (ORCID: https://orcid.org/0000-0001-9508-8209)
- Feifan Zhang (ORCID: https://orcid.org/0000-0002-1992-089X)
- Jie Dong (ORCID: https://orcid.org/0000-0002-6134-3803)
- Yaqian Zhao (ORCID: https://orcid.org/0000-0002-2449-4370)
- Yan Hu (ORCID: https://orcid.org/0000-0003-2905-9295)
- Yuhua Zhang (ORCID: https://orcid.org/0000-0002-9870-2865)
- Lanlan Sun (ORCID: https://orcid.org/0000-0002-3290-6101)
- P. Li (ORCID: https://orcid.org/0000-0003-4731-1183)
Institutions
- Chinese Academy of Sciences (CN)
- Zhejiang Cancer Hospital (CN)
- Zhejiang Provincial People's Hospital (CN)
- Hangzhou Medical College (CN)
- University College London (GB)
- Beihang University (CN)
Publication Details
- Journal
- Clinical Epigenetics
- Published
- 2024-12-21
- DOI
- https://doi.org/10.1186/s13148-024-01800-0
- Citations
- 4
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 1.13
Funders
- National Natural Science Foundation of China
- Universidade de Macau
- Higher Education Discipline Innovation Project
- Medical Science and Technology Project of Zhejiang Province
- Natural Science Foundation of Zhejiang Province
- Science and Technology Program of Zhejiang Province