Target trial emulation to evaluate the effect of immune-related adverse events on outcomes in metastatic urothelial cancer
Using TTE, we were able to show that the occurrence of irAEs is no longer associated with better survival or improved response rates to ICI in mUC patients, in contrast to the naïve analysis. These findings demonstrate that TTE is a suitable formal framework to avoid immortal time bias in studies with time-dependent non-interventional exposures.
Authors
- Hanno Ulmer (ORCID: https://orcid.org/0000-0001-5911-1002)
- Andreas Kronbichler (ORCID: https://orcid.org/0000-0002-2945-2946)
- Laura S. Mertens (ORCID: https://orcid.org/0000-0003-3317-6427)
- Sarah Maier
- David D‘Andrea (ORCID: https://orcid.org/0000-0003-1625-1077)
- Josef Fritz (ORCID: https://orcid.org/0000-0003-1342-3435)
- Dora Niedersuess‐Beke (ORCID: https://orcid.org/0000-0003-0544-5773)
- Keiichiro Mori (ORCID: https://orcid.org/0000-0002-6147-6569)
- Benjamin Pradère (ORCID: https://orcid.org/0000-0002-7768-8558)
- Karl H. Tully
- Thomas Bauernhofer (ORCID: https://orcid.org/0000-0001-9124-4876)
- Roman Mayr (ORCID: https://orcid.org/0000-0003-1796-3260)
- Jeremy Yuen‐Chun Teoh (ORCID: https://orcid.org/0000-0002-9361-2342)
- José Daniel Subiela (ORCID: https://orcid.org/0000-0003-4176-8174)
- Melanie R. Hassler (ORCID: https://orcid.org/0000-0002-9496-4411)
- Ekaterina Laukhtina (ORCID: https://orcid.org/0000-0002-8953-0272)
- Renate Pichler (ORCID: https://orcid.org/0000-0001-5286-9048)
- Shahrokh François Shariat (ORCID: https://orcid.org/0000-0002-6627-6179)
- Kilian M. Gust
- Johanna Krauter
- Marco Moschini (ORCID: https://orcid.org/0000-0002-3084-2458)
- Jasmin Alija Spiegelberg
- Lea Korber
Institutions
- Jikei University School of Medicine (JP)
- Innsbruck Medical University (AT)
- Vita-Salute San Raffaele University (IT)
- Chinese University of Hong Kong (HK)
- Universidad de Alcalá (ES)
- Universität Innsbruck (AT)
- Medical University of Graz (AT)
- Cornell University (US)
- Charles University (CZ)
- The Netherlands Cancer Institute (NL)
- Universitätsklinik Marien Hospital Herne (DE)
- Comprehensive Cancer Center Vienna (AT)
- Instituto Ramón y Cajal de Investigación Sanitaria (ES)
- Lyon Genou Centre Albert Trillat (FR)
- IRCCS Ospedale San Raffaele (IT)
- Hospital Universitario Ramón y Cajal (ES)
- University of Regensburg (DE)
- Medical University of Vienna (AT)
- The University of Texas Southwestern Medical Center (US)
- Ruhr University Bochum (DE)
Publication Details
- Journal
- Cancer Immunology Immunotherapy
- Published
- 2024-12-21
- DOI
- https://doi.org/10.1007/s00262-024-03871-7
- Citations
- 1
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.28