A retrospective study of relationship of total antioxidant defense and total oxidative stress and level of serum ferritin in type-2 diabetes

Introduction: Oxidative stress has been implicated in chronic diseases like Diabetes Mellitus and the antioxidant defense status gets reduced. Ferritin is an acute positive phase reactant, the level of which gets elevated in chronic diseases like Diabetes Mellitus.Aims and Objectives: Whether there is any relation among the markers of oxidative status and the serum ferritin levels in type-2 Diabetes patients is the main objective of the study.Materials and Methods: Simple colorimetric assay methods were applied to measure Total Antioxidant Defense (TAD) & Total Oxidative Stress (TOS) in serum samples. Ferritin level is estimated by ELISA method with standardized kits.Results: Level of TOS was significantly elevated in cases compared to controls, whereas the level of TAD was observed significantly higher in control group than the cases. Serum ferritin level was found significantly increased in the cases in comparison to the control group. There is a negative correlation among TOS level and TAD levels among cases and controls. There is a strong positive correlation among the levels of TOS and serum ferritin and a negative correlation between TAD and ferritin levels.Conclusion: Instead of TOS and TAD levels, serum ferritin levels can be used to assess the oxidative status of a type-2 Diabetes patient.