[One new galloyl derivative from Isodon henryi].
Seven compounds(1-7) were isolated from Isodon henryi through silica gel, Sephadex LH-20, ODS, MCI column chromatography and semi-preparative HPLC. Their structures were identified as isogallicacid(1), caffeic acid(2), syringic acid(3), protocatechuic acid(4), oresbiusin A(5), lophanthoside A(6), and 8-hydroxypinoresinol(7), by spectroscopic techniques including HR-MS, IR, UV, NMR, and ECD. Compound 1 was a new galloyl derivative. Moreover, it demonstrated a significant inhibitory effect on the lipopolysaccharide-induced release of nitric oxide from RAW264.7 cells.
Authors
- Liping Dai (ORCID: https://orcid.org/0000-0002-1910-7591)
- Jun Chi (ORCID: https://orcid.org/0000-0002-9325-1196)
- Zhimin Wang (ORCID: https://orcid.org/0000-0003-1889-7162)
- Yixiao Li (ORCID: https://orcid.org/0009-0004-0614-4395)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- China Academy of Chinese Medical Sciences (CN)
- First Affiliated Hospital of Henan University (CN)
- Sichuan Academy of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- PubMed
- Published
- 2024-11-01
- DOI
- https://doi.org/10.19540/j.cnki.cjcmm.20240806.201
- Primary Topic
- Bioactive Natural Diterpenoids Research
- Type
- article