Safety and Efficacy of Intravenous Thrombolysis by Infarct Type in Patients with No Visible Occlusion: A Secondary Analysis of the AcT Trial
In the AcT trial, safety of intravenous thrombolysis was similar across all infarct types in patients with no visible occlusion but functional outcomes were worst in patients with nonlacunar infarct. Safety and functional outcomes after intravenous thrombolysis were better in the groups with lacunar infarct and no visible infarct as compared with the overall trial population.
Authors
- Aleksander Tkach (ORCID: https://orcid.org/0009-0009-4063-4431)
- A. Zohaib Siddiqi (ORCID: https://orcid.org/0000-0002-5228-6376)
- Andrew M. Demchuk (ORCID: https://orcid.org/0000-0002-4930-7789)
- Brian H Buck (ORCID: https://orcid.org/0000-0002-7984-6062)
- Mohammed Almekhlafi (ORCID: https://orcid.org/0000-0001-9550-8197)
- Dar Dowlatshahi (ORCID: https://orcid.org/0000-0003-1379-3612)
- Katrina Hannah D. Ignacio (ORCID: https://orcid.org/0000-0001-7263-8474)
- Gary Hunter (ORCID: https://orcid.org/0000-0003-2033-8001)
- Michel Christopher Frank Shamy (ORCID: https://orcid.org/0000-0002-0085-6816)
- Rick Swartz (ORCID: https://orcid.org/0000-0001-6571-5531)
- Nishita Singh (ORCID: https://orcid.org/0000-0003-3647-0904)
- Ankur Wadhwa (ORCID: https://orcid.org/0000-0003-4898-8495)
- Fouzi Bala (ORCID: https://orcid.org/0000-0001-6748-2081)
- Chitapa Kaveeta (ORCID: https://orcid.org/0000-0001-8316-6820)
- Thalia Shoshana Field (ORCID: https://orcid.org/0000-0002-1176-0633)
- Ayoola Ademola (ORCID: https://orcid.org/0000-0002-8412-6246)
- Luciana Catanese (ORCID: https://orcid.org/0000-0002-8696-5211)
- Bijoy K. Menon (ORCID: https://orcid.org/0000-0002-3466-496X)
- Tolulope T. Sajobi (ORCID: https://orcid.org/0000-0002-5696-5552)
- Ramana Appireddy (ORCID: https://orcid.org/0000-0003-1831-5804)
- Atif Zafar (ORCID: https://orcid.org/0000-0002-2738-5225)
Institutions
- Université de Tours (FR)
- St. Michael's Hospital (CA)
- Sunnybrook Health Science Centre (CA)
- Siriraj Hospital (TH)
- University of British Columbia (CA)
- University of Ottawa (CA)
- University of Alberta (CA)
- University of Calgary (CA)
- Queen's University (CA)
- Mahidol University (TH)
- Ottawa Hospital (CA)
- Kelowna General Hospital (CA)
- Health Sciences Centre (CA)
- University of Saskatchewan (CA)
- Centre Hospitalier Universitaire de Tours (FR)
- Ontario Brain Institute (CA)
- University of Manitoba (CA)
- Hamilton Health Sciences (CA)
- McMaster University (CA)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2024-12-20
- DOI
- https://doi.org/10.1161/jaha.124.037577
- Citations
- 2
- Primary Topic
- Acute Ischemic Stroke Management
- Type
- article
- Field-Weighted Citation Impact
- 0.77
Funders
- Heart and Stroke Foundation of Canada
- Alberta Innovates
- Canadian Institutes of Health Research