Effects of vagus nerve stimulation on daily function and quality of life in markedly treatment-resistant major depression: Findings from a one-year, randomized, sham-controlled trial
Active VNS was superior to sham VNS in improving QoL and psychosocial function in patients with TRD. VNS has a broader therapeutic impact than symptom improvement alone in patients with marked psychosocial impairment.
Authors
- Mark S. George (ORCID: https://orcid.org/0000-0003-1767-1815)
- Bryan Olin
- Ziad Nahas (ORCID: https://orcid.org/0000-0002-8391-5673)
- Mark T. Bunker (ORCID: https://orcid.org/0000-0001-5871-0687)
- Jeffrey I. Bennett
- James W. Murrough (ORCID: https://orcid.org/0000-0001-6286-1242)
- Harold A. Sackeïm (ORCID: https://orcid.org/0000-0002-1107-4553)
- Rebecca M. Allen (ORCID: https://orcid.org/0000-0002-7880-6958)
- Kevin Reeves (ORCID: https://orcid.org/0000-0002-3799-119X)
- Brian J. Mickey (ORCID: https://orcid.org/0000-0002-7847-7680)
- S Majewski (ORCID: https://orcid.org/0009-0004-8747-3755)
- Cristina Cusin (ORCID: https://orcid.org/0000-0002-6334-9918)
- Charles R. Conway (ORCID: https://orcid.org/0000-0001-6849-9416)
- Lucian Manu
- Ying-Chieh Lee (ORCID: https://orcid.org/0000-0002-5414-5497)
- Peter B. Rosenquist (ORCID: https://orcid.org/0000-0001-9919-3380)
- Jeffrey C. Way (ORCID: https://orcid.org/0000-0002-6676-3188)
- Patricio Riva‐Posse (ORCID: https://orcid.org/0000-0002-5887-0557)
- David L. Dünner
- Yvette I. Sheline (ORCID: https://orcid.org/0000-0002-6929-9659)
- Gustavo Alva (ORCID: https://orcid.org/0000-0001-9742-398X)
- John Zajecka (ORCID: https://orcid.org/0000-0001-8398-636X)
- João Quevedo (ORCID: https://orcid.org/0000-0003-3114-6611)
- Heather Luing (ORCID: https://orcid.org/0009-0006-8263-1552)
- A. John Rush (ORCID: https://orcid.org/0000-0003-1908-9474)
- Scott T. Aaronson (ORCID: https://orcid.org/0000-0003-1333-4045)
- Jonathan Essary Becker
Institutions
- University of Minnesota (US)
- Emory University (US)
- Medical University of South Carolina (US)
- Southern Illinois University School of Medicine (US)
- Washington University in St. Louis (US)
- University of Missouri–St. Louis (US)
- University of Utah (US)
- Augusta University (US)
- St. Augustine College (US)
- Huntsman Cancer Institute (US)
- The Ohio State University Wexner Medical Center (US)
- Psychiatric Medicine Associates (US)
- Stony Brook School (US)
- Massachusetts General Hospital (US)
- Brentwood Hospital (US)
- Sheppard Pratt Health System (US)
- Florida Center for Dermatology (US)
- Duke-NUS Medical School (SG)
- LivaNova (United Kingdom) (GB)
- Ralph H. Johnson VA Medical Center (US)
- ATP Clinical Research (United States) (US)
- Center for Anxiety and Depression (US)
- Stony Brook University (US)
- University of Pennsylvania (US)
- The University of Texas Health Science Center at Houston (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Brain stimulation
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1016/j.brs.2024.12.1187
- Citations
- 17
- Primary Topic
- Vagus Nerve Stimulation Research
- Type
- article
- Field-Weighted Citation Impact
- 4.21
Funders
- Massachusetts General Hospital
- University of Pennsylvania
- Ohio State University
- Emory University
- Texas Tech University
- Washington University in St. Louis
- Carilion Clinic
- LivaNova
- McGovern Medical School
- University of California, San Diego
- Perelman School of Medicine, University of Pennsylvania
- Dell Medical School, University of Texas at Austin