Concordance & discordance analysis between LDLc and apolipoprotein B/Non HDLc among statin treated patients

Background: Atherogenic lipoproteins are the major determinant of atherosclerotic cardiovascular diseases (ASCVD). Lipid derived ASCVD risk is traditionally been calculated by LDLc level. There are growing evidences that only LDLc value may not be comprehensive while assessing CV risk. There is considerable discordance among different Lipid parameters particularly in statin treated patients.Objective: We aimed to look at relationship between apolipoprotein B/ non HDlc and LDLc in statin treated patients.We enrolled patients who were at high risk for ASCVDs & were on stable statin therapy. After detail explanation of study procedure, informed consent was taken from each eligible patient. Then 12 hours fasting blood samples were taken for estimation of lipid profile, apolipoprotein-B. Appropriate statistical tests were done to see concordance & discordance pattern among different lipid parameters.Results: Among 65 enrolled patients, mean age was 53±9.60 years. Among ASCVD major risk factors hypertension was present in 63% patients, diabetes was present in 49.2 % patients. Although 75.4 % patients were at LDLc goal but 52.3 % patients were not achieved their ethnicity specific apolipoprotein-B goal with statin therapy. The correlation between apolipoprotein B and LDL cholesterol was found to be moderate and positive (r=0.460, p<0> Conclusion: We need to identify those subset of statin treated patients who remain at high risk for ASCVD events despite attaining optimal LDLc goal due to presence of discordantly high appolipoprotien-B/non HDLc level.