Evaluation of Napsin A and CK5/6 Expression in Non-Small Cell Lung Carcinoma (NSCLC): An Immunohistochemical Study

Background: Lung cancer is the most common type of cancer and the principal cause of death from cancer worldwide. This study aimed to evaluate the expression of Napsin A and CK5/6 in NSCLC, correlate immunohistochemical results of Napsin A and CK5/6 in differentiating between adenocarcinoma and SCC of the lung. assessment of the expression pattern of Napsin A and CK 5/6 as regard the available clinicopathological data available. Methods: This retrospective study was carried upon 40 lung cases; included 26 adenocarcinoma cases (Resection) and 14 cases of squamous cell carcinoma (Including 7 resection cases and 7 bronchoscopic biopsy cases). Results: Highly significant increase in CK5/6 score and expression, in SSC group; compared to ADC group (p < 0.001). ADC had a highly significant positive correlation with Napsin A score (p < 0.01). In the current study Pearson’s correlation analysis shows that; SSC, had a highly significant positive correlation with CK5/6 score. Conclusion: From our findings we can conclude that Napsin A score can predicted patients with ADC from patients with SSC. the increase in SSC histology; had an independent effect on increasing the probability of CK5/6 expression. the decrease in LN; had an independent effect on increasing the probability of Napsin A expression.