Schiff bases performance and challenge: Chemical synthesis and current state of biological activities

Several structure incorporating Schiff bases found multiple applications in different field. Several therapeutic compounds in the anti-cancer, anti-hypertensive, anti-microbial, anti-fungal, and anti-ulcer segments have been produced using the moiety, which has become an essential anchor for the creation of novel pharmacologically active medicines. Since they are pharmacophoric and synthetically possible, Schiff bases have been actively sought after in the creation of novel derivatives and analogues. As a result, they have become one of the most sought-after and essential pharmacophores for drug development. A broad range of biological activities have been made possible by the different substituents and their varying patterns surrounding the Schiff base nucleus. Furthermore, theses moiety serves as a building block for the synthesis of several lead compounds, novel chemical entities, and therapeutic candidates.