Study the Relationship between the Platelet Parameters and Hyperlipidemia

Background:Platelet volume indices (PVI), encompassing parameters such as platelet distribution width (PDW), mean platelet volume (MPV), and the platelet-large cell ratio (P-LCR), are routinely accessible through standard clinical laboratory assays and serve as valuable biomarkers for predicting the likelihood of thrombotic complications. Objective: This work aimed to assess and to evaluate the platelet parameters and functions in hyperlipidemic patients. Subjects and methods: This cross-sectional study was carried out on 50 patients aged ≥ 18 years old, both sexes, diagnosed with hyperlipidemia (Group 1) and 30 healthy individuals as control (Group 2).Adenosine diphosphate (ADP) aggregation test was done for all patients. Results: Platelet count was positively correlated with body mass index (BMI), triglycerides (TG), low-density lipoprotein (LDL-C), very low-density lipoprotein (VLDL-C), cholesterol, ADP, MPV, PDW, P-LCR, plateletcrit (PCT). PDW was positively correlated with TG, LDL-C, VLDL-C, ADP, cholesterol, BMI, MPV, P-LCR, and PCT. P-LCR was positively correlated with TG, LDL-C, VLDL-C, ADP, cholesterol, BMI, PDW, MPV, and PCT. PCT was positively correlated with TG, LDL-C, VLDL-C, ADP, cholesterol, BMI, MPV, PDW, and P-LCR. Platelet count, MPV, PDW, P-LCR, PCT and ADP were significantly lower in patients in the borderline high TG and cholesterol group than the high TGand cholesterol group (P<0.05). MPV, PDW, P-LCR, PCT and ADP were significantly lower in the borderline high LDL-C group than the high LDL-C group and the very high LDL-C group (P<0.05). Conclusions: Total cholesterol, LDL-C, high-density lipoprotein (HLDL-C), and TG influence the values of PVI. Lipids and lipoproteins interact with platelets and affect their structure (Platelet membrane lipid) and function (platelet aggregation).