Evaluation of leptin and lipid profile parameters in patients of T2DM in a tertiary care center of the Kumaun region of Uttarakhand

Introduction: In India, T2DM is a major health problem due to its rising prevalence and associated complications. The role and mechanism of leptin and insulin in the etiopathogenesis of type 2 diabetes mellitus have been studied and reviewed in varying ethnic populations. However in the Kumaun region of Uttarakhand studies regarding the association of leptin and insulin in type 2 diabetes are lacking, for this the present study was conducted.Materials and Methods: A total of 100 subjects, including fifty known T2DM patients and fifty healthy Age, Gender [Manish1] and BMI matched controls were[Manish2] enrolled in this cross-sectional study. Anthropometric and biochemical parameters including leptin, insulin, fasting glucose, HbA1c, and lipid profile were estimated in all the subjects by standard protocols.Results: Higher leptin levels (p< 0 r=0.346, r=0,482,> Conclusions: High leptin levels are associated with insulin resistance and dyslipidemia in diabetic cases in this region.