Exosomal ANXA2 facilitates ovarian cancer peritoneal metastasis by activating peritoneal mesothelial cells through binding with TLR2
Exosomal ANXA2 secreted by tumour cells activates HPMCs and induces the expression of LCN2, which in turn promotes the peritoneal metastasis of OvCa.
Authors
- Jingni Zhang (ORCID: https://orcid.org/0000-0003-4675-7853)
- Qiulei Wu (ORCID: https://orcid.org/0000-0002-6232-9528)
- Zehua Wang (ORCID: https://orcid.org/0000-0002-5659-9409)
- Lingling Gao (ORCID: https://orcid.org/0000-0003-4603-0945)
- Jing Yan Cai (ORCID: https://orcid.org/0000-0001-6934-0108)
- Hongmei Liu (ORCID: https://orcid.org/0000-0002-5118-9793)
- Tong Liu (ORCID: https://orcid.org/0000-0003-0482-0738)
- Xiaoqing Yi (ORCID: https://orcid.org/0000-0002-4931-900X)
- Xiaoli Liu (ORCID: https://orcid.org/0009-0006-0634-2652)
Institutions
- Union Hospital (HK)
- Wuhan University (CN)
- Zhongnan Hospital of Wuhan University (CN)
- Wuhan Union Hospital (CN)
- Union Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2024-12-21
- DOI
- https://doi.org/10.1186/s12964-024-01987-y
- Citations
- 9
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 2.10
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hubei Province