Immunosuppressant drug tacrolimus inhibits HUVEC angiogenesis and production of placental growth factor
An acute tacrolimus exposure reduced PlGF secretion and impaired angiogenesis in primary endothelial cells, without affecting. These findings provide a potential mechanistic basis for tacrolimus to contribute to the endothelial dysfunction contributing to preeclampsia.
Authors
- David J. Nikolic‐Paterson (ORCID: https://orcid.org/0000-0001-5734-2931)
- Jennifer H. Yo (ORCID: https://orcid.org/0000-0002-0618-1813)
- Sarah A. Marshall (ORCID: https://orcid.org/0000-0001-7276-1405)
- Kirsten Rebecca Palmer (ORCID: https://orcid.org/0000-0001-7421-6291)
- Peter G. Kerr (ORCID: https://orcid.org/0000-0002-3178-849X)
Institutions
- Monash Health (AU)
- Monash University (AU)
- Monash Institute of Medical Research (AU)
Publication Details
- Journal
- Placenta
- Published
- 2024-12-21
- DOI
- https://doi.org/10.1016/j.placenta.2024.12.010
- Citations
- 1
- Primary Topic
- Cardiovascular Issues in Pregnancy
- Type
- article
- Field-Weighted Citation Impact
- 0.40