Fulminant clostridioides (costridium) difficile infection caused by a rare strain of PCR-ribotype 153 in Japan: A case report
Clostridioides (Clostridium) difficile (C. difficile) infection (CDI), often severe when producing toxin A, toxin B, and CDT, can cause life-threatening fulminant infections, especially in vulnerable patients. This case report discusses a 39-year-old woman with no medical history who developed severe CDI after antibiotic treatment, leading to fatal hypovolemic shock. A rare C. difficile PCR-ribotype 153 strain, which is positive for toxin A, toxin B, and CDT was identified. This case emphasizes the need for early CDI diagnosis, cautious antibiotic use, and prompt treatment to prevent severe outcomes like shock and multiorgan failure.
Authors
- Suguru Hasegawa (ORCID: https://orcid.org/0000-0002-8641-8197)
- Akio Uchiyama
- Hiroyasu Kaya (ORCID: https://orcid.org/0000-0002-5513-5661)
- Shinjiro Horikawa
- Yoshinao Koshida
- Masahiko Nakamura (ORCID: https://orcid.org/0000-0003-4893-1552)
- Koichiro Matsuda (ORCID: https://orcid.org/0009-0009-5125-1129)
- Daichi Yomogida (ORCID: https://orcid.org/0000-0003-0571-6617)
- Mitsutoshi Senoh
- Shiori Mizuta
Institutions
- Intensive Care Foundation (AU)
- National Institute of Infectious Diseases (JP)
- Toyama Prefectural Central Hospital (JP)
Publication Details
- Journal
- Anaerobe
- Published
- 2024-12-21
- DOI
- https://doi.org/10.1016/j.anaerobe.2024.102936
- Primary Topic
- Clostridium difficile and Clostridium perfringens research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Agency for Medical Research and Development