Neonates exposed to HIV but uninfected exhibit an altered gut microbiota and inflammation associated with impaired breast milk antibody function
nHEU exhibits profound alterations in gut bacterial microbiota with a mild impact on the enteric DNA virome. Elevated inflammation in nHEU could be due to a lower capacity of breast milk IgA from mothers living with HIV to limit growth the of gut bacteria associated with inflammation. Video Abstract.
Authors
- Christian Diener (ORCID: https://orcid.org/0000-0002-7476-0868)
- Brandon S. Maust (ORCID: https://orcid.org/0000-0002-3174-9036)
- Meghan A. Koch (ORCID: https://orcid.org/0000-0002-9539-4027)
- Bryan P. Brown (ORCID: https://orcid.org/0000-0002-4476-6150)
- Clive M. Gray (ORCID: https://orcid.org/0000-0002-9293-901X)
- Berenice Alinde (ORCID: https://orcid.org/0000-0002-3240-8014)
- Sean M. Gibbons (ORCID: https://orcid.org/0000-0002-8724-7916)
- Adam J. Byrne (ORCID: https://orcid.org/0000-0003-2736-8174)
- Heather B. Jaspan (ORCID: https://orcid.org/0000-0002-0745-6073)
- Donald Nyangahu (ORCID: https://orcid.org/0000-0003-3592-3967)
- Colin Feng
Institutions
- Rutgers, The State University of New Jersey (US)
- University of Cape Town (ZA)
- Egerton University (KE)
- University of Washington (US)
- Medical University of Graz (AT)
- Stellenbosch University (ZA)
- Institute for Systems Biology (US)
- Fred Hutch Cancer Center (US)
- Seattle Children's Hospital (US)
- Donaldson (United States) (US)
Publication Details
- Journal
- Microbiome
- Published
- 2024-12-20
- DOI
- https://doi.org/10.1186/s40168-024-01973-z
- Citations
- 9
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 2.10