Relationship between circulating miRNA-222-3p and miRNA-136-5p and the efficacy of docetaxel chemotherapy in metastatic castration-resistant prostate cancer patients
Our study demonstrates that miRNA-136-5p promotes the proliferation and invasion of PC3 and DU145 cells while inhibiting apoptosis. Circulating miRNA-222-3p may serve as a biomarker for early therapeutic response to docetaxel, and further clinical investigation is warranted. Additionally, miRNA-136-5p may have anti-cancer effects during docetaxel chemotherapy in metastatic castration-resistant prostate cancer.
Authors
- Shuai Yuan (ORCID: https://orcid.org/0000-0001-5055-5627)
- Yue Niu (ORCID: https://orcid.org/0000-0001-5735-4959)
- Peng Chen (ORCID: https://orcid.org/0000-0003-3463-0708)
- Xing Bi
- Furhati Shayiti
Institutions
- Xinjiang Medical University (CN)
- Tumor Hospital of Xinjiang Medical University (CN)
Publication Details
- Journal
- BMC Urology
- Published
- 2024-12-21
- DOI
- https://doi.org/10.1186/s12894-024-01666-7
- Citations
- 2
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.57
Funders
- Natural Science Foundation of Xinjiang