Brain derived β-interferon is a potential player in Alzheimer’s disease pathogenesis and cognitive impairment
Our findings demonstrate that distinct inflammatory molecules are associated with different cognitive disorders. Notably, CSF IFN-β levels are significantly linked to the pathology and cognitive performance of AD, identifying this interferon as a potential target for AD therapy.
Authors
- Shufen Yuan
- Allan I. Levey (ORCID: https://orcid.org/0000-0002-3153-502X)
- Jiong Shi (ORCID: https://orcid.org/0000-0001-7694-1366)
- Mengguo Zhang
- Yaxi Zhan
- Qiong Wang (ORCID: https://orcid.org/0000-0002-1043-7826)
- Feng Gao (ORCID: https://orcid.org/0000-0002-7539-6455)
- Chenxi Wang (ORCID: https://orcid.org/0009-0003-8705-8546)
- Yong Shen (ORCID: https://orcid.org/0000-0002-5048-8134)
- Duntao Huang
Institutions
- University of Science and Technology of China (CN)
- Emory University (US)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2024-12-21
- DOI
- https://doi.org/10.1186/s13195-024-01644-z
- Citations
- 5
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 1.20
Funders
- National Natural Science Foundation of China