Baseline echocardiographic variables as predictors of hemodynamically significant cytokine release syndrome in adults treated with CD19 CAR T-cell therapy for hematological malignancies
No specific echocardiographic variables predicted the development of CRS ≥ 2, and therefore the mechanism leading to hemodynamic decompensation and producing worsening hypoxia and hypotension could be multifactorial and not directly cardiac mediated.
Authors
- Jonas Paludo (ORCID: https://orcid.org/0000-0002-7350-5531)
- Eduardo Tellez‐Garcia (ORCID: https://orcid.org/0000-0001-5358-1433)
- Hector R. Villarraga (ORCID: https://orcid.org/0000-0002-3675-6948)
- Allison Rosenthal (ORCID: https://orcid.org/0000-0002-8915-3163)
- Muhannad Abbasi (ORCID: https://orcid.org/0000-0002-2774-542X)
- M Roa (ORCID: https://orcid.org/0000-0001-7777-9372)
- Andres Daryanani (ORCID: https://orcid.org/0009-0007-8425-4225)
- Yi Lin (ORCID: https://orcid.org/0000-0002-1556-6416)
- Juan Manuel Garzón-Dangond
- Joerg Herrmann (ORCID: https://orcid.org/0000-0001-6675-4559)
- Stephen M. Ansell
Institutions
- Mayo Clinic (US)
- Mayo Clinic in Arizona (US)
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- Cardio-Oncology
- Published
- 2024-12-21
- DOI
- https://doi.org/10.1186/s40959-024-00290-6
- Citations
- 4
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 1.13
Funders
- Center for Clinical and Translational Science, Mayo Clinic