Differential associations of anti-cytomegalovirus antibodies and soluble CD14 levels with immunosenescence in people living with HIV on long term antiretroviral therapy
Thus, higher levels of immune activation and immunosenescence in the cases possibly indicate their compromised immune status predisposing PLHIV to infections and cancers. The study indicated a need for CMV treatment regimens even in asymptomatic individuals for preventing immunosenescence. The study also indicated a role of dolutegravir induced loss of sCD14 levels in predisposing PLHIV to immunosenescence.
Authors
- Ujjwala Ghule
- Jyoti Sawant (ORCID: https://orcid.org/0000-0003-1702-3631)
- Pallavi Shidhaye (ORCID: https://orcid.org/0000-0002-3903-2830)
- Amrita Rao (ORCID: https://orcid.org/0000-0003-2950-9938)
- Manisha Ghate (ORCID: https://orcid.org/0000-0003-4222-4611)
- Ashwini Shete (ORCID: https://orcid.org/0000-0003-0791-2128)
- Smita Kumbhar (ORCID: https://orcid.org/0000-0002-3030-9477)
- Rajani Bagul
- Supriya Deshpande
- Nikita Bhawari
Institutions
- National AIDS Research Institute (IN)
Publication Details
- Journal
- Immunity & Ageing
- Published
- 2024-12-21
- DOI
- https://doi.org/10.1186/s12979-024-00491-8
- Citations
- 2
- Primary Topic
- Cytomegalovirus and herpesvirus research
- Type
- article
- Field-Weighted Citation Impact
- 0.77
Funders
- Indian Council of Medical Research