Leucinostatins target Plasmodium mitochondria to block malaria transmission
We conclude that the leucinostatins pass through the cytoplasmic membrane without lysing cells and interact with molecules specifically in mitochondria. Therefore, leucinostatins should be ideal inhibitors against mobile parasites, such as ookinetes and sporozoites, during malaria transmission.
Authors
- Guodong Niu (ORCID: https://orcid.org/0000-0002-1406-6698)
- Jun Li (ORCID: https://orcid.org/0000-0002-2121-3393)
- Xiaohong Wang (ORCID: https://orcid.org/0000-0002-9445-2408)
Institutions
- Florida International University (US)
Publication Details
- Journal
- Parasites & Vectors
- Published
- 2024-12-20
- DOI
- https://doi.org/10.1186/s13071-024-06608-8
- Citations
- 1
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 0.54
Funders
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases