Elevated Galectin-3 levels in the tumor microenvironment of ovarian cancer – implication of ROS mediated suppression of NK cell antitumor response via tumor-associated neutrophils
Taken together, our results demonstrate high levels of Galectin-3 in the tumormicroenvironment of HGSC. High levels of Galectin-3 may induce production of reactiveoxygen species in ascites neutrophils in some patients. In turn, reactive oxygen species produced by neutrophils may modulate the NK cell anti-tumor immunity. Together, this study suggests further investigation to evaluate if a Galectin-3-targeting therapy may be used in ovarian cancer.
Authors
- Karin Christenson (ORCID: https://orcid.org/0000-0003-2489-2253)
- Maria Lycke (ORCID: https://orcid.org/0000-0002-1371-4649)
- Martina Sundqvist (ORCID: https://orcid.org/0000-0002-0859-0792)
- Elin Bernson (ORCID: https://orcid.org/0000-0001-6414-5725)
- Anneli Ivarsson (ORCID: https://orcid.org/0000-0001-8944-2558)
- Karin Sundfeldt (ORCID: https://orcid.org/0000-0002-7135-3132)
- Veronika Karlsson (ORCID: https://orcid.org/0000-0001-9423-9378)
- Hakon Leffler (ORCID: https://orcid.org/0000-0003-4482-8945)
- Ebba Stål
- Emma Stoopendahl
Institutions
- Lund University (SE)
- University of Gothenburg (SE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-12-20
- DOI
- https://doi.org/10.3389/fimmu.2024.1506236
- Citations
- 4
- Primary Topic
- Galectins and Cancer Biology
- Type
- article
- Field-Weighted Citation Impact
- 0.96
Funders
- Åke Wiberg Stiftelse
- Swedish Cancer Foundation
- Cancerfonden
- Stiftelserna Wilhelm och Martina Lundgrens
- Svenska Sällskapet för Medicinsk Forskning
- Vetenskapsrådet
- Stiftelsen Assar Gabrielssons Fond
- Svenska Läkaresällskapet
- Reumatikerförbundet
- Stiftelsen Mary von Sydows, född Wijk, donationsfond