NEUROGLOBIN IN CINGULATE CORTEX NEURONS OF THE RAT BRAIN IN CHOLESTASIS

Вackground. The study of neuroglobin will help to understand the mechanisms of neuroprotection and energy metabolism in neurons of different cingulate cortex layers in cholestasis. Objective. To evaluate the immunoreactivity of neuroglobulin in cingulate cortex neurons of the rat brain in cholestasis. Material and methods. Neurons of the 2nd and 5th layers of the anterior cingulate cortex of the rat brain were studied at different times after ligation/transection of the common bile duct (CBD) or sham surgery (control). Histological, immunohistochemical, morphometric, and statistical methods were used. Results. Immunoreactivity of neuroglobin in neurons of the 2nd and 5th layers of the anterior cingulate cortex of the rat brain after transection of the common bile duct changes in a wave-like manner, reaching peaks on the 5th and 10th days in the small-cell layer and on the 10th and 20th days in the large-cell layer, then it decreases and returns to control values by the 90th day. Conclusion. Neurons of the small-cell layer (according to neuroglobin expression) react more quickly to cholestasis and normalize sooner after its disappearance, compared with neurons of the large-cell layer of the cingulate cortex.