Targeting CEA in metastatic triple negative breast cancer with image-guided radiation followed by Fab-mediated chimeric antigen receptor (CAR) T-cell therapy
These findings demonstrate that the combination of IGRT and anti-CEA scFab CAR-T therapy induces a strong antitumor response, effectively targeting both the primary tumor and distant metastatic lesions in the lungs, thus demonstrating that IGRT enhances CAR-T cell infiltration, persistence, and overall efficacy within both primary and metastatic lesions.
Authors
- Paul J. Yazaki (ORCID: https://orcid.org/0000-0003-2626-3303)
- Christine E. Brown (ORCID: https://orcid.org/0000-0003-4915-8207)
- John E. Shively (ORCID: https://orcid.org/0000-0002-7763-770X)
- Hemendra Ghimire
- Xiuli Wang (ORCID: https://orcid.org/0000-0001-5964-4327)
- Dennis Awuah (ORCID: https://orcid.org/0000-0002-4295-5599)
- Susanta Hui
- Maciej Kujawski (ORCID: https://orcid.org/0000-0002-9701-5211)
- Eric Aniogo
- Edward Seung
- Ruby Espinosa
Institutions
- City Of Hope National Medical Center (US)
- City of Hope (US)
- Beckman Research Institute
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-12-20
- DOI
- https://doi.org/10.3389/fimmu.2024.1499471
- Citations
- 1
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.28
Funders
- National Cancer Research Institute