Sex hormone imbalance and rheumatoid arthritis in American men: a cross-sectional analysis from NHANES 2011–2016
This study provides evidence that low testosterone and high SHBG levels are associated with an increased risk of RA in men. These associations are nonlinear and modified by factors such as age, race/ethnicity, hypertension, and PIR. Our findings highlight the importance of considering hormonal status in RA risk assessment and suggest potential avenues for targeted therapeutic strategies aimed at hormonal regulation.
Authors
- Shou‐Ye Hu (ORCID: https://orcid.org/0000-0002-8724-2306)
- Pengfei Wen (ORCID: https://orcid.org/0000-0001-8873-5172)
- Yidian Wang
- Mingyi Yang (ORCID: https://orcid.org/0000-0001-8640-9795)
- Lin Liu (ORCID: https://orcid.org/0000-0003-1894-4723)
- Xiaomeng Qiao (ORCID: https://orcid.org/0000-0003-3094-0266)
- Zhi Yang (ORCID: https://orcid.org/0009-0003-1586-3001)
- Peng Yang (ORCID: https://orcid.org/0009-0006-7637-7885)
Institutions
- Xi'an Honghui Hospital (CN)
- Xi'an Jiaotong University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-12-20
- DOI
- https://doi.org/10.3389/fimmu.2024.1501257
- Citations
- 3
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 1.41
Funders
- Yakult Bio-Science Foundation