Activation of mechanoreceptor Piezo1 inhibits enteric neuronal growth and migration in vitro
Mechanotransduction plays an important role in regulating normal GI function. Our results suggest that the Piezo1 mechanoreceptor may play an important role in the ENS as its activation leads to decreased neuronal growth and migration. Piezo1 could be an important target for diseases of ENS dysfunction and development.
Authors
- Swathi Balaji (ORCID: https://orcid.org/0000-0001-8875-8008)
- Lily S. Cheng (ORCID: https://orcid.org/0000-0001-5125-7197)
- Sundeep G. Keswani (ORCID: https://orcid.org/0000-0002-8820-0706)
- Britney A. Hsu
- Xinyu Zhou (ORCID: https://orcid.org/0000-0003-2620-7360)
- Oluyinka O. Olutoye (ORCID: https://orcid.org/0000-0003-1619-3970)
- Chengli Shen (ORCID: https://orcid.org/0000-0003-4731-2872)
- Chioma Moneme (ORCID: https://orcid.org/0000-0003-1025-5827)
- Yuwen Zhang (ORCID: https://orcid.org/0000-0001-8915-1769)
- Hui Li (ORCID: https://orcid.org/0000-0002-2108-0201)
- Arabinda Mandal (ORCID: https://orcid.org/0009-0008-4365-8749)
- Michał F. Sobstel
- Jacob L. Kaminer
- Ling Yu
Institutions
- Baylor College of Medicine (US)
- Texas Children's Hospital (US)
- University of Virginia (US)
Publication Details
- Journal
- Frontiers in Molecular Neuroscience
- Published
- 2024-12-20
- DOI
- https://doi.org/10.3389/fnmol.2024.1474025
- Citations
- 1
- Primary Topic
- Erythrocyte Function and Pathophysiology
- Type
- article
- Field-Weighted Citation Impact
- 0.33
Funders
- American College of Surgeons
- Baylor College of Medicine
- National Institutes of Health
- National Heart, Lung, and Blood Institute
- National Institute of Diabetes and Digestive and Kidney Diseases