Cognitive decline profiles associated with lewy pathology in the context of Alzheimer’s disease neuropathologic change
LP and ADNC differentially affected cross-sectional and longitudinal cognitive profiles in a large autopsy sample. Concomitant Braak V-VI neurofibrillary tangle pathology had a strong impact on clinical progression in those with LP, regardless of the initial stage. Thus, LB and ADNC co-pathology interact to affect cognitive domains that may be used to track Lewy Body disease longitudinally and as outcome measures in therapeutic trials.
Authors
- Melissa J. Armstrong (ORCID: https://orcid.org/0000-0002-2163-1907)
- Jon B. Toledo (ORCID: https://orcid.org/0000-0003-4366-9268)
- David P. Salmon (ORCID: https://orcid.org/0000-0003-4533-4090)
- Douglas Galasko
Institutions
- Houston Methodist (US)
- University of Florida (US)
- University of California San Diego (US)
- Methodist Hospital (US)
- Florida College (US)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2024-12-20
- DOI
- https://doi.org/10.1186/s13195-024-01628-z
- Citations
- 4
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 1.54
Funders
- Florida Department of Health
- Demensförbundet
- National Institutes of Health
- National Institute on Aging