Causal Relationships Between Epilepsy, Anti‐Epileptic Drugs, and Serum Vitamin D and Vitamin D Binding Protein: A Bidirectional and Drug Target Mendelian Randomization Study
No causal relationships were found between genetically determined serum 25(OH)D levels, VDBP, and epilepsy or its subtypes. Furthermore, the use of AEDs, such as Carbamazepine, Oxcarbazepine, Progabide, and Valproic Acid, reduces serum 25(OH)D levels, while not affect VDBP levels.
Authors
- Guoming Luan (ORCID: https://orcid.org/0000-0001-5084-2458)
- Zizhang Cheng (ORCID: https://orcid.org/0000-0002-6560-0280)
- Xiaohui Peng (ORCID: https://orcid.org/0000-0002-9804-0152)
- Yuguang Guan
- Jinyi Zuo
- Wenlong Su (ORCID: https://orcid.org/0000-0002-5647-3988)
- Haoran Zhang (ORCID: https://orcid.org/0000-0001-9792-7600)
Institutions
- Capital Medical University (CN)
- Beijing Sanbo Brain Hospital (CN)
- Chinese Institute for Brain Research (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1111/cns.70183
- Citations
- 1
- Primary Topic
- Pharmacological Effects and Toxicity Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.11